Genes and their role
4. Compare the number of chromosome in body cells vs sex cells.
5. Identify the role of cell division in reproduction.
6. Identify the role of X and Y chromosomes in determining gender
Henry the Eighth married six women, two of whom he divorced and two he executed -- all in the attempt to have a male heir, a son to continue his line. His first wife had only a daughter to survive, with 5 stillbirths. Anne Boleyn had a daughter, who later became Elizabeth 1. Henry had an heir, Edward VI, with his third wife, Jane Seymour, but Edward died at the age of 15, possibly from tuberculosis. His next three wives did not produce children. [Divorced=beheaded=died=divorced=beheaded=survived.]
Henry blamed the lack of male heirs on his wives, and produced reasons to have them removed as queen. What does science say about this?
The determination of genetic sex happens at the moment of fertilisation (conception).
Human body cells have 46 chromosomes in 23 pairs, with one of each pair coming from the mother, and the other of each pair coming from the father. Each one in pairs 1-22 matches its partner in size, shape and characteristics. The 23rd pair, called the sex chromosomes because they help determine whether a person will develop male or female sex characteristics, come in two different types, called the X-chromosome and the Y-chromosome.
A female is typically XX, a male is typically XY. If a baby inherits two X chromosomes, one from each parent, it will be genetically female. If a baby inherits an X from the mother and a Y from the father, it will be genetically male.
The SRY gene, the gene for maleness, is found only on the Y-chromosome and provides instructions for making a protein called the Sex-determining Region Y protein. This protein starts processes that cause a foetus to develop male gonads (testes) and prevent the development of female reproductive structures (uterus and fallopian tubes).
Born in 1861, American geneticist Nettie Maria Stevens devoted her career to studying the life of beetles. In 1905 she observed that male beetles produced two types of sperm, one that carried a large chromosome, while the other, a small chromosome. When fertilized with a female egg, the large chromosome would produce female offspring and the small chromosome would produce male offspring.
Having noticed these chromosome differences applied to humans as well as other animals, Stevens developed the concept of the X-Y determination system, which stated that female offspring were determined by two large sex chromosomes (XX) and male offspring by a large and small sex chromosome (XY). Fellow geneticist Edmund Beecher Wilson discovered the same findings in his independent research a little after this, but Wilson received the credit.
Photo: Fine Art Images/Heritage Images/Getty ImagesAdapted from https://www.biography.com/news/alice-ball-female-scientistsView the PowerPoint below left (10 slides)
Complete the Worksheet below right (1 page)
Match chromosomes to form a karyotype in this online interactive https://learn.genetics.utah.edu/content/basics/karyotype/
View and interact with the PowerPoint below left (10 slides)
Check understanding with the PowerPoint below right (4 slides)
Complete the Worksheet (1 page)