1. Why am I unique?
1.1 Distinguish between inherited (genetic) and acquired (environmental) characteristics.
1.2 Investigate the structure of DNA.
1.3 Relate DNA base sequences to the production of particular proteins, resulting in an organism’s traits.
1.4 Draw and interpret a flowchart describing the relationship between DNA, genes and chromosomes.
1.5 Model the steps to identify the role of meiosis (cell division) in halving the number of chromosomes as gametes (male and female sex cells) are formed.
1.6 Describe how fertilisation combines the chromosomes in the male and female sex cells to form new combinations of genes in the zygote.
1.7 Define mutation and identify causes, including through DNA replication.
1.8 Give examples and explain how mutations can give advantages or disadvantages to an organism.
Glossary of terms:
As we move through this topic, there are some terms you may come across that you will need to understand, and some others that may be helpful. Start a glossary of terms.
Essential:
alleles, anaphase, asexual reproduction, binary fission, bioethics, biotechnology, chromosome, cloning, cytokinesis, daughter cell, DNA, diploid, dominant, embryo, ethical, gamete, gene, genotype, gonad, haploid, heredity, heterozygous, homozygous, hybrid, inheritance, interphase, in-vitro, meiosis, metaphase, mitosis, mutation, offspring, phenotype, probability, prophase, Punnett square, purebred, recessive, replication, sex determination, sexual reproduction, stem-cell research, telophase, traits, zygote
Extension terms:
independent assortment, co-dominance, incomplete dominance, sex-linked inheritance
Reference Text pages 46,47.
To understand why people are so different, we need to go deep inside the cell to the chromosomes in the nucleus. It will be helpful to compare the process in organisms that do not produce different offspring different to the parent (asexual reproduction) with the process in other organisms that produce offspring different to the parents (sexual reproduction).
Notes:
the term offspring is used in genetics to describe the "children" because we are talking about a whole range of different living things, including plants, not just people.
the presence of a- at the start of a word means the word is the opposite (eg symptomatic = having symptoms, asymptomatic means not having symptoms).
View video:
Asexual and Sexual Reproduction https://www.youtube.com/watch?v=fcGDUcGjcyk [5.09 mins]
Complete: Amoeba Sisters Worksheet from video (2 pages)
Note: Australians spell fertilisation with an -s-, Americans spell it with a -z-.
Complete: Summary Table - The two main types of reproduction
View videos:
Sexual Reproduction Overview https://www.youtube.com/watch?v=jOVbTpLZfd0 [3.32 mins]
Note: Australians pronounce the term meiosis as my-osis not me-osis. More on that process later.
Sexual Reproduction in Humans https://www.youtube.com/watch?v=-ekRRuSa_UQ [4.13 mins}
DNA stands for deoxyribonucleic acid, which is a long and complex molecule that contains the unique genetic code of each human and almost all other organisms, including some viruses. Nearly every cell in an organism has the same DNA. In the way that a computer code gives instructions to programs, DNA gives instructions - but these instructions are for making all the proteins in our bodies. Where a computer code is based on different combinations of 0s and 1s, the information in DNA is stored as a code made up of different combinations of four chemical bases: adenine (A), cytosine (C), guanine (G) and thymine (T).
DNA sequences form genes that are found on chromosomes in the nucleus of most cells (mature red blood, skin, hair, and nail cells do not contain DNA).
60% of our DNA is the same as the DNA in strawberries and other fruit!
Review from Year 8:
What are Proteins? https://learn.genetics.utah.edu/content/basics/proteins/ [0.59 mins]
From the diagram below, write what you think it is showing about how the five different images are related.
Gently "mush" the banana in the Ziplock bag for about a minute until all the lumps are gone and the banana almost looks like custard.
Fill a cup with the hot water and 1 teaspoon of salt and stir to dissolve.
Pour the saltwater mix into the bag. Close the bag and very gently squeeze and move the saltwater and banana mush together for 30 - 45 seconds.
Add the dishwashing soap into the bag and gently mix the contents. Try to avoid making too much foam.
Place the coffee filter in a clear glass cup, securing the top of the filter around the lip of the cup.
Pour the mix into the filter and let it sit until all of the liquid drips down into the cup.
Remove and discard the used coffee filter.
Tilt the glass and slowly add cold alcohol down the side of the cup. You want the alcohol to form a layer on top of the banana mix, staying separated, so be careful not to pour it too fast. Make a layer of alcohol that is about 2-3cm thick.
After the alcohol layer is set up, wait for eight minutes. You may see some bubbles and cloudy material moving around in the alcohol. This is the DNA pieces clumping together.
Use the wooden stirrer to start poking the DNA in the alcohol layer. Spin the stirrer it in place to start gathering the DNA. Take a closer look at the DNA.
Text page 8 Practical 1.1
1. View PPT: DNA below left - 44 slides (many are just small changes to the previous slide)
2. Complete Worksheet below right - 2 pages
Photo: Donaldson Collection/Michael Ochs Archives/Getty Images
Born in 1920 in London, Rosalind Franklin was a chemist, X-ray crystallographer and leading molecular biologist who discovered the structure of DNA.
In 1951 Franklin became a research associate at King's College in London where she used X-ray crystallography techniques on DNA. A year later Franklin captured an image of the molecule's structure, identifying it as Photo 51.
While doing her research, however, her relationship with her colleague Maurice Wilkins became unpleasant, so she left King's College and continued her work at Birkbeck College.
Unknown to Franklin, Wilkins took Photo 51 and shared it with Francis Crick and James Watson, who used her research to publish their double-helix theory of DNA in 1953. Franklin published her own separate research on the same theory shortly thereafter. However, her manuscript was dismissed as merely confirming her male colleagues' discovery.
In 1958, aged 37, Franklin died from ovarian cancer, never knowing her research was stolen. Four years later, Wilkins, Crick and Watson would go on to receive the Nobel Peace Prize for their double-helix theory of DNA. Watson would later author the book, The Double Helix, in which he continued to credit himself and his male colleagues for their award-winning discovery and to describe Franklin as an antagonistic and overly-emotional woman.
Adapted from https://www.biography.com/news/alice-ball-female-scientistsComplete: Science World Worksheet 11.2 DNA
Create a model showing the double helical structure of DNA. Some ideas follow in the image carousel.
Complete: Text page 7 Questions 1-12, 15, 18
Explore: Stile Learning (Cosmos) DNA Is it Useful?
Cells are limited in the size they can reach, so when a multi-cell organism grows, its individual cells do not grow bigger, it makes new cells. When cells reproduce themselves, the DNA in the nucleus must replicate (make a copy of) itself.
The following short video is just to show in simple form how that quite complex process happens. It is not required learning (it is in the Y12 Biology course.)
View video:
DNA replication https://www.youtube.com/watch?v=z685FFqmrpo&feature=related [1.02 mins]
Mitosis (pronounced my-tosis) is one of two processes where cells divide to form "daughter cells".
Mitosis is the process by which:
cells make copies of themselves so the organism can grow
OR
single-cell animals reproduce (produce new individuals) in asexual reproduction.
Text Reference pages 12-16
View video:
Mitosis Animation https://www.youtube.com/watch?v=ofjyw7ARP1c&vl=en [5.42 mins]
View video: Mitosis the Amoeba Sisters https://www.youtube.com/watch?v=f-ldPgEfAHI [8.26 mins]
Complete: Worksheet
Ref Text page 19 Practical 1
Ref Text page 19 Practical 2
View PPT:
Cell Cycle - 43 slides
The process is important to uderstand, but you do not need to remember the names of the phases (eg metaphase), although their names help to inderstand the process:
inter means in between - the cell is in between dividing phases
pro means early - the start of the dividing process
meta means middle - the chromosomes line up in the middle of the nucleus
ana - is like antagonistic - the chromososmes move away from each other as if they didn't like each other
telo - the nucleus starts to 'telescope' in, forming two nuclei
cyto - cytoplasm, kinesis - kinetic, movement - the cytoplasm splits and two new cells form
and back to inter - in between phase
Stages of Mitosis - 4 pages
Cell Cycle Mitosis - 5 pages, from the PPT (apologies for Google Drive changing formatting in Pages 4-5!)
Mitosis and the Cell Cycle https://www.footprints-science.co.uk/index.php?quiz=Mitosis_and_the_cell_cycle
Meiosis (pronounced my-osis) is the process of cell division with the only purpose that of sexual reproduction. Two sex cells combine in sexual reproduction, so if the sex cells were the same as all other cells - carrying the normal amount of chromosomes, then the "daughter" cell would have double the chromosome number, the next generation would have 4 times as much... and cells would burst!
Meiosis reduces the chromosome number to one half, so that two sex cells combining result in just the normal numbes of chromosomes in every new generation.
Meiosis has some of the same steps as mitosis, with a few more added that reduce the chromosome number to half.
Text Reference pages 12-16
View video: Meiosis Amoeba Sisters https://www.youtube.com/watch?v=VzDMG7ke69g [7.43 mins]
Complete: Worksheet
View PPT:
Meiosis - 43 slides
View video:
Meiosis 3D Animation https://www.youtube.com/watch?v=c5hA0WCv1lg [6.43 mins]
Complete Worksheet: Science Focus 4 Meiosis
Complete Worksheet: Core Science 11.4 SW Meiosis
Each method of cell division has a purpose in reproduction. What is it, and does it give an advantage?
View video:
Amoeba Sisters Mitosis vs Meiosis https://www.youtube.com/watch?v=zrKdz93WlVk&feature=youtu.be [6.21 mins]
View PPT:
Mitosis vs Meiosis - 10 pages
View video:
Mitosis vs Meiosis Rap Battle https://www.youtube.com/watch?v=qH4WUUQ5pOI [3.01 mins]
Complete Worksheet:
Mitosis and Meiosis Review WS - 3 pages
Mitosis vs Meiosis https://www.footprints-science.co.uk/index.php?quiz=Mitosis_vs_meiosis
Use the information you have gained from the previous tasks to construct a Venn diagram, using the template. Keep the comparison points on the same lines (eg blue/yellow, not blue/tall.)